Studies on Chemotherapeutics. XXXVI

Clinical studies of induction agents. XXXVI: Ketamine.

The intravenous anaesthetic ketamine has been given to patients undergoing minor gynaecological surgery after atropine prcmedication in initial doses ranging from 1.0 to 3.0 mg/kg. The chief induction complications were hypertension and hypertonus, the incidence of which was only broadly related to dosage. Recovery of consciousness was rapid, though marred by a high incidence of delirium at all...

Notes on Some Remedies. XXXVI. Penicillin

The COPD Pipeline XXXVI.

Contract Pharma is a publication that reviews, among other things, the pharmaceutical industry annually. Those of us who work in chronic obstructive pulmonary disease (COPD) take an interest in the source of the drugs we use and Contract Pharma brings that information to us. Each year they report the status of the top 25 pharmaceutical companies.1 For each pharma, a report lists the newly appro...

Antifungal chemotherapeutics.

This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...

Nanoformulations of Antimicrobial Chemotherapeutics

Bacterial infections represent an increasing worldwide threat. The number of untreatable diseases decreased after the 1950s due to the introduction of antimicrobial agents. However, since the 1980s, morbidity has risen again, and mortality due to respiratory infections, AIDS and tuberculosis now represents about 85% of world mortality from infections [1,2]. The increase in the number of new inf...